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Modified Dukes criteria voor endocarditis

Major diagnostic criteria
Positive blood culture for typical infective endocarditis organisms (S.viridans or S.bovis, HACEK, S.aureus without other primary site, Enterococcus), from 2 separate blood cultures or 2 positive cultures from samples drawn >12 hours apart, or 3 or a majority of 4 separate cultures of blood (first and last sample drawn 1 hour apart)
Echocardiogram with oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or an implanted material in the absence of an alternative anatomic explanation, or abscess, or new partial dehiscence of prosthetic valve or new valvular regurgitation
Single positive blood culture for Coxiella burnetii or anti-phase 1 IgG antibody titer >1:800
Minor diagnostic criteria
Predisposing heart condition or intravenous drug use
Temp >38.0 C
Vascular phenomena: arterial emboli, pulmonary infarcts, mycotic aneursyms, intracranial bleed, conjunctival hemorrhages, Janeway lesions
Immunologic phenomena: glomerulonephritis, Osler nodes, Roth spots, rheumatoid factor
Microbiological evidence: positive blood culture but does not meet a major criterion or serological evidence of active infection with organism consistent with endocarditis (excluding coat neg staph, and other common contaminants)


Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization
of specific echocardiographic findings. Duke Endocarditis Service. American Journal of
. 96(3):200-9, 1994.